diff --git a/sysdeps/x86/cpu-features.c b/sysdeps/x86/cpu-features.c
index e501e084ef..c096dd390a 100644
--- a/sysdeps/x86/cpu-features.c
+++ b/sysdeps/x86/cpu-features.c
@@ -870,11 +870,18 @@ init_cpu_features (struct cpu_features *cpu_features)
 
 	      /* Newer Bigcore microarch (larger non-temporal store
 		 threshold).  */
-	    case INTEL_BIGCORE_SKYLAKE:
-	    case INTEL_BIGCORE_KABYLAKE:
-	    case INTEL_BIGCORE_COMETLAKE:
 	    case INTEL_BIGCORE_SKYLAKE_AVX512:
 	    case INTEL_BIGCORE_CANNONLAKE:
+	      /* Benchmarks indicate non-temporal memset is not
+		     necessarily profitable on SKX (and in some cases much
+		     worse). This is likely unique to SKX due its it unique
+		     mesh interconnect (not present on ICX or BWD). Disable
+		     non-temporal on all Skylake servers. */
+	      cpu_features->preferred[index_arch_Avoid_Non_Temporal_Memset]
+		  |= bit_arch_Avoid_Non_Temporal_Memset;
+	    case INTEL_BIGCORE_COMETLAKE:
+	    case INTEL_BIGCORE_SKYLAKE:
+	    case INTEL_BIGCORE_KABYLAKE:
 	    case INTEL_BIGCORE_ICELAKE:
 	    case INTEL_BIGCORE_TIGERLAKE:
 	    case INTEL_BIGCORE_ROCKETLAKE:
diff --git a/sysdeps/x86/cpu-tunables.c b/sysdeps/x86/cpu-tunables.c
index 89da7a03da..ae9dcd6180 100644
--- a/sysdeps/x86/cpu-tunables.c
+++ b/sysdeps/x86/cpu-tunables.c
@@ -243,6 +243,11 @@ TUNABLE_CALLBACK (set_hwcaps) (tunable_val_t *valp)
 		(n, cpu_features, MathVec_Prefer_No_AVX512, AVX512F, 24);
 	    }
 	  break;
+	case 25:
+	  {
+	    CHECK_GLIBC_IFUNC_PREFERRED_BOTH (n, cpu_features,
+					      Avoid_Non_Temporal_Memset, 25);
+	  }
 	case 26:
 	    {
 	      CHECK_GLIBC_IFUNC_PREFERRED_NEED_BOTH
diff --git a/sysdeps/x86/dl-cacheinfo.h b/sysdeps/x86/dl-cacheinfo.h
index 5e77345a6e..a1c03b8903 100644
--- a/sysdeps/x86/dl-cacheinfo.h
+++ b/sysdeps/x86/dl-cacheinfo.h
@@ -991,13 +991,14 @@ dl_init_cacheinfo (struct cpu_features *cpu_features)
   /* Non-temporal stores are more performant on Intel and AMD hardware above
      non_temporal_threshold. Enable this for both Intel and AMD hardware. */
   unsigned long int memset_non_temporal_threshold = SIZE_MAX;
-  if (cpu_features->basic.kind == arch_kind_intel
-      || cpu_features->basic.kind == arch_kind_amd)
-      memset_non_temporal_threshold = non_temporal_threshold;
-
-   /* For AMD CPUs that support ERMS (Zen3+), REP MOVSB is in a lot of
-      cases slower than the vectorized path (and for some alignments,
-      it is really slow, check BZ #30994).  */
+  if (!CPU_FEATURES_ARCH_P (cpu_features, Avoid_Non_Temporal_Memset)
+      && (cpu_features->basic.kind == arch_kind_intel
+	  || cpu_features->basic.kind == arch_kind_amd))
+    memset_non_temporal_threshold = non_temporal_threshold;
+
+  /* For AMD CPUs that support ERMS (Zen3+), REP MOVSB is in a lot of
+     cases slower than the vectorized path (and for some alignments,
+     it is really slow, check BZ #30994).  */
   if (cpu_features->basic.kind == arch_kind_amd)
     rep_movsb_threshold = non_temporal_threshold;
 
diff --git a/sysdeps/x86/include/cpu-features-preferred_feature_index_1.def b/sysdeps/x86/include/cpu-features-preferred_feature_index_1.def
index 85e7f54ec8..61bbbc2e89 100644
--- a/sysdeps/x86/include/cpu-features-preferred_feature_index_1.def
+++ b/sysdeps/x86/include/cpu-features-preferred_feature_index_1.def
@@ -33,3 +33,4 @@ BIT (Prefer_No_AVX512)
 BIT (MathVec_Prefer_No_AVX512)
 BIT (Prefer_FSRM)
 BIT (Avoid_Short_Distance_REP_MOVSB)
+BIT (Avoid_Non_Temporal_Memset)
diff --git a/sysdeps/x86/tst-hwcap-tunables.c b/sysdeps/x86/tst-hwcap-tunables.c
index 8589a9fd66..94307283d7 100644
--- a/sysdeps/x86/tst-hwcap-tunables.c
+++ b/sysdeps/x86/tst-hwcap-tunables.c
@@ -60,7 +60,7 @@ static const struct test_t
     /* Disable everything.  */
     "-Prefer_ERMS,-Prefer_FSRM,-AVX,-AVX2,-AVX512F,-AVX512VL,"
     "-SSE4_1,-SSE4_2,-SSSE3,-Fast_Unaligned_Load,-ERMS,"
-    "-AVX_Fast_Unaligned_Load",
+    "-AVX_Fast_Unaligned_Load,-Avoid_Non_Temporal_Memset",
     test_1,
     array_length (test_1)
   },
@@ -68,7 +68,7 @@ static const struct test_t
     /* Same as before, but with some empty suboptions.  */
     ",-,-Prefer_ERMS,-Prefer_FSRM,-AVX,-AVX2,-AVX512F,-AVX512VL,"
     "-SSE4_1,-SSE4_2,-SSSE3,-Fast_Unaligned_Load,,-,"
-    "-ERMS,-AVX_Fast_Unaligned_Load,-,",
+    "-ERMS,-AVX_Fast_Unaligned_Load,-Avoid_Non_Temporal_Memset,-,",
     test_1,
     array_length (test_1)
   }
