diff --git a/gcc/common/config/i386/i386-common.cc b/gcc/common/config/i386/i386-common.cc
index 6c3bebb1846..ec94251dd4c 100644
--- a/gcc/common/config/i386/i386-common.cc
+++ b/gcc/common/config/i386/i386-common.cc
@@ -388,6 +388,46 @@ set_malign_value (const char **flag, unsigned value)
   *flag = r;
 }
 
+/* Emit a warning when using -mno-avx512{f,vl,bw,dq,cd,bf16,fp16,vbmi,vbmi2,
+   vnni,ifma,bitalg,vpopcntdq} with -mavx10.1 and above.  */
+static bool
+ix86_check_avx10 (struct gcc_options *opts)
+{
+  if (opts->x_ix86_isa_flags2 & opts->x_ix86_isa_flags2_explicit
+      & OPTION_MASK_ISA2_AVX10_1)
+    {
+      warning (0, "%<-mno-avx512{f,vl,bw,dq,cd,bf16,fp16,vbmi,vbmi2,vnni,ifma,"
+	       "bitalg,vpopcntdq}%> are ignored with %<-mavx10.1%> and above");
+      return false;
+    }
+
+  return true;
+}
+
+/* Emit a warning when using -mno-avx10.1 with -mavx512{f,vl,bw,dq,cd,bf16,
+   fp16,vbmi,vbmi2,vnni,ifma,bitalg,vpopcntdq}.  */
+static bool
+ix86_check_avx512 (struct gcc_options *opts)
+{
+  if ((opts->x_ix86_isa_flags & opts->x_ix86_isa_flags_explicit
+       & (OPTION_MASK_ISA_AVX512F | OPTION_MASK_ISA_AVX512CD
+	  | OPTION_MASK_ISA_AVX512DQ | OPTION_MASK_ISA_AVX512BW
+	  | OPTION_MASK_ISA_AVX512VL | OPTION_MASK_ISA_AVX512IFMA
+	  | OPTION_MASK_ISA_AVX512VBMI | OPTION_MASK_ISA_AVX512VBMI2
+	  | OPTION_MASK_ISA_AVX512VNNI | OPTION_MASK_ISA_AVX512VPOPCNTDQ
+	  | OPTION_MASK_ISA_AVX512BITALG))
+      || (opts->x_ix86_isa_flags2 & opts->x_ix86_isa_flags2_explicit
+	  & (OPTION_MASK_ISA2_AVX512FP16 | OPTION_MASK_ISA2_AVX512BF16)))
+    {
+      warning (0, "%<-mno-avx10.1%> is ignored when using with "
+	       "%<-mavx512{f,vl,bw,dq,cd,bf16,fp16,vbmi,vbmi2,vnni,"
+	       "ifma,bitalg,vpopcntdq}%>");
+      return false;
+    }
+
+  return true;
+}
+
 /* Implement TARGET_HANDLE_OPTION.  */
 
 bool
@@ -609,7 +649,7 @@ ix86_handle_option (struct gcc_options *opts,
 	  opts->x_ix86_isa_flags |= OPTION_MASK_ISA_AVX512F_SET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512F_SET;
 	}
-      else
+      else if (ix86_check_avx10 (opts))
 	{
 	  opts->x_ix86_isa_flags &= ~OPTION_MASK_ISA_AVX512F_UNSET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512F_UNSET;
@@ -624,7 +664,7 @@ ix86_handle_option (struct gcc_options *opts,
 	  opts->x_ix86_isa_flags |= OPTION_MASK_ISA_AVX512CD_SET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512CD_SET;
 	}
-      else
+      else if (ix86_check_avx10 (opts))
 	{
 	  opts->x_ix86_isa_flags &= ~OPTION_MASK_ISA_AVX512CD_UNSET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512CD_UNSET;
@@ -898,7 +938,7 @@ ix86_handle_option (struct gcc_options *opts,
 	  opts->x_ix86_isa_flags |= OPTION_MASK_ISA_AVX512VBMI2_SET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512VBMI2_SET;
 	}
-      else
+      else if (ix86_check_avx10 (opts))
 	{
 	  opts->x_ix86_isa_flags &= ~OPTION_MASK_ISA_AVX512VBMI2_UNSET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512VBMI2_UNSET;
@@ -913,7 +953,7 @@ ix86_handle_option (struct gcc_options *opts,
 	  opts->x_ix86_isa_flags |= OPTION_MASK_ISA_AVX512FP16_SET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512FP16_SET;
 	}
-      else
+      else if (ix86_check_avx10 (opts))
 	{
 	  opts->x_ix86_isa_flags2 &= ~OPTION_MASK_ISA2_AVX512FP16_UNSET;
 	  opts->x_ix86_isa_flags2_explicit |= OPTION_MASK_ISA2_AVX512FP16_UNSET;
@@ -926,7 +966,7 @@ ix86_handle_option (struct gcc_options *opts,
 	  opts->x_ix86_isa_flags |= OPTION_MASK_ISA_AVX512VNNI_SET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512VNNI_SET;
 	}
-      else
+      else if (ix86_check_avx10 (opts))
 	{
 	  opts->x_ix86_isa_flags &= ~OPTION_MASK_ISA_AVX512VNNI_UNSET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512VNNI_UNSET;
@@ -940,7 +980,7 @@ ix86_handle_option (struct gcc_options *opts,
 	  opts->x_ix86_isa_flags_explicit
 	    |= OPTION_MASK_ISA_AVX512VPOPCNTDQ_SET;
 	}
-      else
+      else if (ix86_check_avx10 (opts))
 	{
 	  opts->x_ix86_isa_flags &= ~OPTION_MASK_ISA_AVX512VPOPCNTDQ_UNSET;
 	  opts->x_ix86_isa_flags_explicit
@@ -954,7 +994,7 @@ ix86_handle_option (struct gcc_options *opts,
 	  opts->x_ix86_isa_flags |= OPTION_MASK_ISA_AVX512BITALG_SET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512BITALG_SET;
 	}
-      else
+      else if (ix86_check_avx10 (opts))
 	{
 	  opts->x_ix86_isa_flags &= ~OPTION_MASK_ISA_AVX512BITALG_UNSET;
 	  opts->x_ix86_isa_flags_explicit
@@ -970,7 +1010,7 @@ ix86_handle_option (struct gcc_options *opts,
 	  opts->x_ix86_isa_flags |= OPTION_MASK_ISA_AVX512BW_SET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512BW_SET;
 	}
-      else
+      else if (ix86_check_avx10 (opts))
 	{
 	  opts->x_ix86_isa_flags2 &= ~OPTION_MASK_ISA2_AVX512BF16_UNSET;
 	  opts->x_ix86_isa_flags2_explicit |= OPTION_MASK_ISA2_AVX512BF16_UNSET;
@@ -1037,7 +1077,7 @@ ix86_handle_option (struct gcc_options *opts,
 	  opts->x_ix86_isa_flags |= OPTION_MASK_ISA_AVX512DQ_SET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512DQ_SET;
 	}
-      else
+      else if (ix86_check_avx10 (opts))
 	{
 	  opts->x_ix86_isa_flags &= ~OPTION_MASK_ISA_AVX512DQ_UNSET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512DQ_UNSET;
@@ -1050,7 +1090,7 @@ ix86_handle_option (struct gcc_options *opts,
 	  opts->x_ix86_isa_flags |= OPTION_MASK_ISA_AVX512BW_SET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512BW_SET;
 	}
-      else
+      else if (ix86_check_avx10 (opts))
 	{
 	  opts->x_ix86_isa_flags &= ~OPTION_MASK_ISA_AVX512BW_UNSET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512BW_UNSET;
@@ -1065,7 +1105,7 @@ ix86_handle_option (struct gcc_options *opts,
 	  opts->x_ix86_isa_flags |= OPTION_MASK_ISA_AVX512VL_SET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512VL_SET;
 	}
-      else
+      else if (ix86_check_avx10 (opts))
 	{
 	  opts->x_ix86_isa_flags &= ~OPTION_MASK_ISA_AVX512VL_UNSET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512VL_UNSET;
@@ -1078,7 +1118,7 @@ ix86_handle_option (struct gcc_options *opts,
 	  opts->x_ix86_isa_flags |= OPTION_MASK_ISA_AVX512IFMA_SET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512IFMA_SET;
 	}
-      else
+      else if (ix86_check_avx10 (opts))
 	{
 	  opts->x_ix86_isa_flags &= ~OPTION_MASK_ISA_AVX512IFMA_UNSET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512IFMA_UNSET;
@@ -1091,7 +1131,7 @@ ix86_handle_option (struct gcc_options *opts,
 	  opts->x_ix86_isa_flags |= OPTION_MASK_ISA_AVX512VBMI_SET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512VBMI_SET;
 	}
-      else
+      else if (ix86_check_avx10 (opts))
 	{
 	  opts->x_ix86_isa_flags &= ~OPTION_MASK_ISA_AVX512VBMI_UNSET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX512VBMI_UNSET;
@@ -1367,7 +1407,7 @@ ix86_handle_option (struct gcc_options *opts,
 	  opts->x_ix86_isa_flags |= OPTION_MASK_ISA_AVX2_SET;
 	  opts->x_ix86_isa_flags_explicit |= OPTION_MASK_ISA_AVX2_SET;
 	}
-      else
+      else if (ix86_check_avx512 (opts))
 	{
 	  opts->x_ix86_isa_flags2 &= ~OPTION_MASK_ISA2_AVX10_1_UNSET;
 	  opts->x_ix86_isa_flags2_explicit |= OPTION_MASK_ISA2_AVX10_1_UNSET;
diff --git a/gcc/config/i386/driver-i386.cc b/gcc/config/i386/driver-i386.cc
index 08d0aed6183..227ace6ff83 100644
--- a/gcc/config/i386/driver-i386.cc
+++ b/gcc/config/i386/driver-i386.cc
@@ -854,7 +854,7 @@ const char *host_detect_local_cpu (int argc, const char **argv)
 		  options = concat (options, " ",
 				    isa_names_table[i].option, NULL);
 	      }
-	    else
+	    else if (isa_names_table[i].feature != FEATURE_AVX10_1)
 	      options = concat (options, neg_option,
 				isa_names_table[i].option + 2, NULL);
 	  }
diff --git a/gcc/testsuite/gcc.target/i386/avx10_1-11.c b/gcc/testsuite/gcc.target/i386/avx10_1-11.c
new file mode 100644
index 00000000000..10c8d781dd9
--- /dev/null
+++ b/gcc/testsuite/gcc.target/i386/avx10_1-11.c
@@ -0,0 +1,5 @@
+/* { dg-do compile { target { ! ia32 } } } */
+/* { dg-options "-O2 -march=x86-64 -mavx10.1 -mno-avx512f" } */
+/* { dg-warning "'-mno-avx512{f,vl,bw,dq,cd,bf16,fp16,vbmi,vbmi2,vnni,ifma,bitalg,vpopcntdq}' are ignored with '-mavx10.1' and above" "" { target *-*-* } 0 } */
+
+#include "avx10_1-1.c"
diff --git a/gcc/testsuite/gcc.target/i386/avx10_1-12.c b/gcc/testsuite/gcc.target/i386/avx10_1-12.c
new file mode 100644
index 00000000000..b79c92ad002
--- /dev/null
+++ b/gcc/testsuite/gcc.target/i386/avx10_1-12.c
@@ -0,0 +1,13 @@
+/* { dg-do compile { target { ! ia32 } } } */
+/* { dg-options "-O2" } */
+
+#include <immintrin.h>
+
+__attribute__ ((target ("avx10.1,no-avx512f"))) void
+f1 ()
+{ /* { dg-warning "'-mno-avx512{f,vl,bw,dq,cd,bf16,fp16,vbmi,vbmi2,vnni,ifma,bitalg,vpopcntdq}' are ignored with '-mavx10.1' and above" } */
+  register __m256d a __asm ("ymm17");
+  register __m256d b __asm ("ymm16");
+  a = _mm256_add_pd (a, b);
+  asm volatile ("" : "+v" (a));
+}
diff --git a/gcc/testsuite/gcc.target/i386/avx10_1-13.c b/gcc/testsuite/gcc.target/i386/avx10_1-13.c
new file mode 100644
index 00000000000..156d59f1d35
--- /dev/null
+++ b/gcc/testsuite/gcc.target/i386/avx10_1-13.c
@@ -0,0 +1,5 @@
+/* { dg-do compile { target { ! ia32 } } } */
+/* { dg-options "-O2 -march=x86-64 -mavx512f -mno-avx10.1" } */
+/* { dg-warning "'-mno-avx10.1' is ignored when using with '-mavx512{f,vl,bw,dq,cd,bf16,fp16,vbmi,vbmi2,vnni,ifma,bitalg,vpopcntdq}'" "" { target *-*-* } 0 } */
+
+#include "avx10_1-2.c"
diff --git a/gcc/testsuite/gcc.target/i386/avx10_1-14.c b/gcc/testsuite/gcc.target/i386/avx10_1-14.c
new file mode 100644
index 00000000000..23d2ba8bc64
--- /dev/null
+++ b/gcc/testsuite/gcc.target/i386/avx10_1-14.c
@@ -0,0 +1,13 @@
+/* { dg-do compile } */
+/* { dg-options "-march=x86-64" } */
+/* { dg-final { scan-assembler "%zmm" } } */
+
+typedef double __m512d __attribute__ ((__vector_size__ (64), __may_alias__));
+
+__attribute__ ((target ("avx512f,no-avx10.1"))) __m512d
+foo ()
+{ /* { dg-warning "'-mno-avx10.1' is ignored when using with '-mavx512{f,vl,bw,dq,cd,bf16,fp16,vbmi,vbmi2,vnni,ifma,bitalg,vpopcntdq}'" } */
+  __m512d a, b;
+  a = a + b;
+  return a;
+}
