diff --git a/DEVELOPERS b/DEVELOPERS
index ac702d8d0f..c8766c872e 100644
--- a/DEVELOPERS
+++ b/DEVELOPERS
@@ -1149,6 +1149,7 @@ F:	package/libxcrypt/
 F:	package/liquid-dsp/
 F:	package/pixiewps/
 F:	package/python-pybind/
+F:	package/python-scipy/
 F:	package/reaver/
 F:	support/testing/tests/package/br2-external/python-pybind
 F:	support/testing/tests/package/sample_python_pybind.py
@@ -1280,6 +1281,8 @@ F:	configs/orangepi_win_defconfig
 F:	configs/orangepi_zero_plus2_defconfig
 F:	configs/pine64_defconfig
 F:	configs/pine64_sopine_defconfig
+F:	package/python-pybind/
+F:	package/python-scipy/
 
 N:	James Hilliard <james.hilliard1@gmail.com>
 F:	package/apcupsd/
diff --git a/package/Config.in b/package/Config.in
index 10209d84d7..0edde1c919 100644
--- a/package/Config.in
+++ b/package/Config.in
@@ -1209,6 +1209,7 @@ menu "External python modules"
 	source "package/python-scandir/Config.in"
 	source "package/python-scapy/Config.in"
 	source "package/python-schedule/Config.in"
+	source "package/python-scipy/Config.in"
 	source "package/python-sdnotify/Config.in"
 	source "package/python-secretstorage/Config.in"
 	source "package/python-see/Config.in"
diff --git a/package/python-scipy/Config.in b/package/python-scipy/Config.in
new file mode 100644
index 0000000000..a016d411af
--- /dev/null
+++ b/package/python-scipy/Config.in
@@ -0,0 +1,30 @@
+config BR2_PACKAGE_PYTHON_SCIPY
+	bool "python-scipy"
+	depends on BR2_PACKAGE_OPENBLAS_ARCH_SUPPORTS # openblas
+	depends on BR2_PACKAGE_PYTHON_NUMPY_ARCH_SUPPORTS # python-numpy
+	depends on BR2_PACKAGE_LAPACK_ARCH_SUPPORTS # lapack
+	depends on BR2_TOOLCHAIN_USES_GLIBC || BR2_TOOLCHAIN_USES_MUSL # python-numpy
+	depends on BR2_TOOLCHAIN_HAS_FORTRAN # lapack
+	depends on BR2_INSTALL_LIBSTDCPP
+	depends on BR2_PACKAGE_PYTHON3
+	select BR2_PACKAGE_LAPACK
+	select BR2_PACKAGE_OPENBLAS
+	select BR2_PACKAGE_ZLIB # runtime scipy::io
+	select BR2_PACKAGE_PYTHON_NUMPY # runtime
+	select BR2_PACKAGE_PYTHON_PYBIND
+	help
+	  The SciPy library is one of the core packages that make up the
+	  SciPy stack. It provides many user-friendly and efficient
+	  numerical routines such as routines for numerical integration,
+	  interpolation, optimization, linear algebra and statistics.
+
+	  https://www.scipy.org/scipylib/
+
+comment "python-scipy needs toolchain w/ fortran and c++ and glibc or musl"
+	depends on BR2_PACKAGE_OPENBLAS_ARCH_SUPPORTS
+	depends on BR2_PACKAGE_PYTHON_NUMPY_ARCH_SUPPORTS
+	depends on BR2_PACKAGE_LAPACK_ARCH_SUPPORTS
+	depends on BR2_PACKAGE_PYTHON3
+	depends on !BR2_TOOLCHAIN_HAS_FORTRAN || \
+		!BR2_INSTALL_LIBSTDCPP || \
+		(!BR2_TOOLCHAIN_USES_GLIBC && !BR2_TOOLCHAIN_USES_MUSL)
diff --git a/package/python-scipy/python-scipy.hash b/package/python-scipy/python-scipy.hash
new file mode 100644
index 0000000000..6f9011516c
--- /dev/null
+++ b/package/python-scipy/python-scipy.hash
@@ -0,0 +1,9 @@
+# Locally generated
+sha256  4042211bed8e6c658b9e2a4ca829806f0b33437faa7878c8dc6d6f72845b1694  scipy-1.7.3.tar.xz
+sha256  32b2f41fb8c1193a066c1686bb3237e79f918685bf545cb6dfcb68753ac35152  LICENSE.txt
+sha256  37e64a498894ac7c3b070023e3689e954a8ecf8a23b90968d09a455f1b4f7b35  scipy/linalg/src/lapack_deprecations/LICENSE
+sha256  606209a000716c5f66e33e180ce08434b96ed17db4975ab9723c6b5fbcc89609  scipy/ndimage/LICENSE.txt
+sha256  3df9207af2fdb861af0ae3b22026f163b9bcfab4e525dc4943afe2ffa3f77624  scipy/optimize/tnc/LICENSE
+sha256  f0cedf52503b2d42b83411a0a16e6fefac346dfad8fddc66f50050150123470c  scipy/sparse/linalg/dsolve/SuperLU/License.txt
+sha256  0926566f9f406178d1214f8cc796e166b1213dd7c05e0c5b461a8b8ac9e50bbe  scipy/sparse/linalg/eigen/arpack/ARPACK/COPYING
+sha256  34db0c0c4f931861d720555c9cd7a2e228d1290ba29af0f2ee80c41bb2038afb  scipy/spatial/qhull_src/COPYING.txt
diff --git a/package/python-scipy/python-scipy.mk b/package/python-scipy/python-scipy.mk
new file mode 100644
index 0000000000..0491a73753
--- /dev/null
+++ b/package/python-scipy/python-scipy.mk
@@ -0,0 +1,63 @@
+################################################################################
+#
+# python-scipy
+#
+################################################################################
+
+PYTHON_SCIPY_VERSION = 1.7.3
+PYTHON_SCIPY_SOURCE = scipy-$(PYTHON_SCIPY_VERSION).tar.xz
+PYTHON_SCIPY_SITE = https://github.com/scipy/scipy/releases/download/v$(PYTHON_SCIPY_VERSION)
+PYTHON_SCIPY_LICENSE = \
+	BSD-3-Clause, \
+	BSD-2-Clause, \
+	BSD, \
+	BSD-Style, \
+	Apache-2.0, \
+	MIT
+PYTHON_SCIPY_LICENSE_FILES = \
+	LICENSE.txt \
+	scipy/linalg/src/lapack_deprecations/LICENSE \
+	scipy/ndimage/LICENSE.txt \
+	scipy/optimize/tnc/LICENSE \
+	scipy/sparse/linalg/dsolve/SuperLU/License.txt \
+	scipy/sparse/linalg/eigen/arpack/ARPACK/COPYING \
+	scipy/spatial/qhull_src/COPYING.txt
+PYTHON_SCIPY_DEPENDENCIES += \
+	host-meson \
+	host-python-numpy \
+	host-python-pythran \
+	zlib \
+	lapack \
+	openblas \
+	python-numpy \
+	python-pybind
+PYTHON_SCIPY_INSTALL_STAGING = YES
+
+PYTHON_SCIPY_SETUP_TYPE = setuptools
+PYTHON_SCIPY_BUILD_OPTS = config_fc --fcompiler=gnu95
+
+# -lnpymath npymath.ini localization
+PYTHON_SCIPY_NPY_PKG_CONFIG_PATH = \
+	$(STAGING_DIR)/usr/lib/python$(PYTHON3_VERSION_MAJOR)/site-packages/numpy/core/lib/npy-pkg-config
+
+PYTHON_SCIPY_LDFLAGS = $(TARGET_LDFLAGS) -shared \
+	-L$(PYTHON3_PATH)/site-packages/numpy/core/lib
+# -lnpyrandom localization
+PYTHON_SCIPY_LDFLAGS += \
+	-L$(STAGING_DIR)/usr/lib/python$(PYTHON3_VERSION_MAJOR)/site-packages/numpy/random/lib
+
+PYTHON_SCIPY_ENV = \
+	F90=$(TARGET_FC) \
+	NPY_PKG_CONFIG_PATH=$(PYTHON_SCIPY_NPY_PKG_CONFIG_PATH) \
+	LDFLAGS="$(PYTHON_SCIPY_LDFLAGS)"
+
+# Provide system configuration options to numpy distutils extenions, telling
+# to find all include files and libraries in staging directory.
+define PYTHON_SCIPY_CONFIGURE_CMDS
+	-rm -f $(@D)/site.cfg
+	echo "[DEFAULT]" >> $(@D)/site.cfg
+	echo "library_dirs = $(STAGING_DIR)/usr/lib" >> $(@D)/site.cfg
+	echo "include_dirs = $(STAGING_DIR)/usr/include" >> $(@D)/site.cfg
+endef
+
+$(eval $(python-package))
